|
Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
TC21 is a Ras-like GTPase with high oncogenic potential that is found mutated in some human tumors and overexpressed in breast cancer cell lines.
|
10557073 |
1999 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical analyses of breast tumors revealed a higher TC21 expression in ER-negative compared with ER-positive tumors.
|
19047159 |
2008 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
Like Ras-transformed cells, NIH 3T3 cells expressing mutant TC21 proteins formed foci of morphologically transformed cells in monolayer cultures, proliferated in low serum, formed colonies in soft agar, and developed progressive tumors in nude mice.
|
8196649 |
1994 |
|
Carcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Significantly, both wild type and mutated RRAS2 (also known as TC21) are overexpressed in human carcinomas of the oral cavity, esophagus, stomach, skin and breast, as well as in lymphomas.
|
24148564 |
2013 |
|
Carcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Previous studies have shown that TC21 is overexpressed in breast, esophageal and oral carcinomas, and that it is closely associated with the early stages of tumorigenesis.
|
20811707 |
2010 |
|
Mammary Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical analyses of breast tumors revealed a higher TC21 expression in ER-negative compared with ER-positive tumors.
|
19047159 |
2008 |
|
Mammary Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We have examined panels of cDNAs from breast, ovarian and cervical cell lines, and primary and metastatic breast tumours for mutations in TC21 using a single-strand conformational polymorphism (SSCP)-based assay.
|
9703274 |
1998 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
TC21 nuclear expression increased from normal oral tissues to leukoplakia and frank malignancy (P < 0.001).
|
20040018 |
2010 |
|
Esophageal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Results suggest that TC21 mediates its effects via the PI3K-Akt pathway, NF-κB and cyclin D1, and enhances chemoresistance in esophageal cancer cells.
|
22919244 |
2012 |
|
Lymphoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Significantly, both wild type and mutated RRAS2 (also known as TC21) are overexpressed in human carcinomas of the oral cavity, esophagus, stomach, skin and breast, as well as in lymphomas.
|
24148564 |
2013 |
|
Malignant neoplasm of mouth
|
0.010 |
Biomarker
|
group |
BEFREE |
The aim of this study was to determine the clinical significance of TC21 in oral cancer.
|
20040018 |
2010 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
TC21 nuclear expression increased from normal oral tissues to leukoplakia and frank malignancy (P < 0.001).
|
20040018 |
2010 |
|
Liver Neoplasms, Experimental
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression and mutation assessment provide clues of genetic and epigenetic mechanisms in liver tumors of oxazepam-exposed mice.
|
21147764 |
2011 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Vitamin D3 measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
|
28757204 |
2017 |
|
Vitamin D measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
|
28757204 |
2017 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
They also provide strong genetic evidence that overexpression of unmutated Rras2 contributes to tumorigenesis, thus suggesting that it may also do so if it is inappropriately expressed in human tumors.
|
12525640 |
2003 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
We conclude that aberrant TC21 function may trigger cellular transformation via a signal transduction pathway similar to that of oncogenic Ras and suggest that deregulated TC21 activity may contribute significantly to human oncogenesis.
|
8196649 |
1994 |
|
Carcinogenesis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
However, little information exists on the function of RRAS2 in tumorigenesis of osteosarcoma.
|
31517733 |
2019 |
|
Carcinogenesis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Previous studies have shown that TC21 is overexpressed in breast, esophageal and oral carcinomas, and that it is closely associated with the early stages of tumorigenesis.
|
20811707 |
2010 |
|
Malignant transformation
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Aberrant function of the Ras-related protein TC21/R-Ras2 triggers malignant transformation.
|
8196649 |
1994 |
|
Malignant transformation
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Aberrant function of RRAS2 drives malignant transformation in a various of cancers.
|
31517733 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we demonstrate that TC21 overexpression promotes the motility of HCC cells in vitro and intrahepatic metastasis in vivo.
|
20811707 |
2010 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our data suggest that TC21 is associated with tumor progression and poor prognosis in HCC.
|
20811707 |
2010 |